Tuesday, January 24, 2012

March 2003, sadly without access

I'm still only reading the abstracts, but in this one there were two that sounded interesting, but I couldn't find them around.

"Early Programming of Adult Longevity: Demographic and Experimental Studies". They look at 100,000 people that died in the 1990s in Kiev and see a "strong association" between the month of the year they were born in and longevity, with the lowest longevity for people born April to July, and highest around December. The July and December low/high agree with what the Gavrilovs found in their studies of aristocratic families (see http://readingrejuvenationresearch.blogspot.com/2011/02/season-of-birth-and-human-longevity.html ) .  On a seemingly completely unrelated study, they look at the lifespan of fruit flies and see them living longer when they are irradiated with low doses of radiation. Their hypothesis is that both effects, and many other anti-aging treatments, are due to the hormetic effect (ie response to low level stressor).  Would like to read this one.

"Neuroprotective, Anti-Apoptotic Effects of Apomorphine". Looks at apomorphine's effects on the brain, with the possible focus on Parkinson's.

"The Role of Somatic and Germline Mutations in Aging and a Mutation Interaction Model of Aging". Another interesting one. Seems like a theoretical paper on the effect of accumulated mutations that don't affect us negatively until past reproductive age. Hypothesises that some of this could increase mutations in non-reproductive cells, leaving different random mutations around the body as we age.

The literature review section looks at a paper which lengthens telomeres in vitro by inserting a short circular bit of DNA matching the telomere repetition sequence's complement. The review has some concerns about validity and missing information to show that this did actually happen.

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