Interestingness:2
By Peter J Hornsby, Khan Ozol, and Keyi Yang, in the Journal of Anti-Aging Medicine, Volume 3, Issue 4 2000 (pp 411-417, doi:10.1089/rej.1.2000.3.411.)
Report on injecting bovine adrenocortical cells into rat brains, after immortalisation via telomerisation and addition of SV40 T antigen, which suppresses p53 and retinoblastoma activation. In one experiment, they also added nerve growth factor (NGF) gene to see if it'd produce it.
Results: lots of immune reaction to the foreign tissue, even when using cyclosporin A, an immunosuppressant, so most cells killed quite quickly.
Also, brief review stating that telomerised cells don't induce tumours in nude mice, and look as if they maintain their cell type.
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