Still mostly reading the abstracts. I managed to get the only paper I would have read out of these from the author's site, so it isn't as big a loss as usual, but I would still like to read the full literature review and dissertations columns.
"Telomeres Shorten with Age in Rat Cerebellum and Cortex in vivo". It seems like they measured telomere length and telomerase activity in 21 day old and 5 month old rat cortices and cerebellums. Shorter telomeres in older. Shorter in cortex than cerebellum. Higher telomerase in older than younger, and in cerebellums than in cortices. All this shortening presumed by authors to be from microglia since only replicating cell in brain. Very well cited paper. Not that interesting to me, but all things telomere seemed to be popular then.
"Will Human Life Expectancy Quadruple in the Next Hundred Years? Sixty Gerontologists Say Public Debate on Life Extension Is Necessary". Survey of gerontologists predicting future life exptectancy.
"Telomerase, Telomerase Inhibition, and Cancer". This one sounded interesting, and I found it on the author's page, so separate post for it.
"Reduced Level of Serum Thiols in Patients with a Diagnosis of Active Disease". Lower serum protein thiols in sick people than in healthy people. Implied lower oxidation in healthy.
"Soy-Induced Brain Atrophy?". Maybe soy lowers BDNF in males.
The literature review column looks at a paper analysing people with skin grafts sourced from their own body and cultured (autologous skin grafts), and seeing shorter telomeres in their grafted bits than in their intact bits. Review mentions that there were only four patients and controls (intact skin) was taken from only two of them. Still, it'd make sense if it was the case. (UPDATE: found the full review. They also look at a paper that finds a negative correlation between telomere length shortening rate in birds and their lifespan)
The first page of the dissertations section had the summary for a thesis on the effect of fitness on the hypothalamic-pituitary-adrenal axis on women, and another for automated brain segmentation from MRI images to measure brain bits as they age, in monkeys.
Tuesday, January 31, 2012
Saturday, January 28, 2012
September 2003 issue
Another one mostly by the abstracts. A couple of interesting things in this one.
"An Ethical Assessment of Anti-Aging Medicine". Ethics.
"A Telomere-Binding Protein (TRF2/MTBP) from Mouse Nuclear Matrix with Motives of an Intermediate Filament-Type Rod Domain". telomere membrane binding protein = telomere repeat factor 2 = (?) protein that binds telomere to nuclear membrane.
"Apparent Induction of Partial Thymic Regeneration in a Normal Human Subject: A Case Report". Growth hormone plus DHEA maybe made the thymus in one person larger and with a larger active region. Rare growth hormone article that I'd be interested in reading.
Report on a meeting for the association and politics for life science. Sounds like mainly ethics.
Report on the 10th congress of the International Association of Biomedical Gerontology, which also seemed to function as a SENS meeting. Found the summary of highlights on the net. Impossible to summarise, but LOTS of interesting papers presented.
Review of the books "The iron factor of aging: why do americans age faster?" which seems to suggest that iron supplementation helps (!?) and one on ethics.
A review of a paper that looks at the link between telomere length and telomerase activity in glioblastomas.
The dissertations section, or at least the first page which I can see, looks at a thesis that compares the hydrogen peroxide production in a bat, a shrew and a mouse, and comes up with them all having similar lifetime free radical production per mitochondrial protein. It also says free radical production in the bat is higher in youth than in old age, which the author says contradicts the free radical theory of aging. She suggests this is due to selection of efficient mitochondria during the lifetime. As far as I understand it, this contradicts de Grey's version of the FRTA too. The thesis was easy to find online from the university's site but I haven't read it properly yet. Interesting nevertheless. The thesis is titled "Aging and mitochondrial efficiency in the little brown bat, Myotis Lucifugus".
The second dissertation mentioned was about the effects of HIV on CD8+ T cell senescence.
"An Ethical Assessment of Anti-Aging Medicine". Ethics.
"A Telomere-Binding Protein (TRF2/MTBP) from Mouse Nuclear Matrix with Motives of an Intermediate Filament-Type Rod Domain". telomere membrane binding protein = telomere repeat factor 2 = (?) protein that binds telomere to nuclear membrane.
"Apparent Induction of Partial Thymic Regeneration in a Normal Human Subject: A Case Report". Growth hormone plus DHEA maybe made the thymus in one person larger and with a larger active region. Rare growth hormone article that I'd be interested in reading.
Report on a meeting for the association and politics for life science. Sounds like mainly ethics.
Report on the 10th congress of the International Association of Biomedical Gerontology, which also seemed to function as a SENS meeting. Found the summary of highlights on the net. Impossible to summarise, but LOTS of interesting papers presented.
Review of the books "The iron factor of aging: why do americans age faster?" which seems to suggest that iron supplementation helps (!?) and one on ethics.
A review of a paper that looks at the link between telomere length and telomerase activity in glioblastomas.
The dissertations section, or at least the first page which I can see, looks at a thesis that compares the hydrogen peroxide production in a bat, a shrew and a mouse, and comes up with them all having similar lifetime free radical production per mitochondrial protein. It also says free radical production in the bat is higher in youth than in old age, which the author says contradicts the free radical theory of aging. She suggests this is due to selection of efficient mitochondria during the lifetime. As far as I understand it, this contradicts de Grey's version of the FRTA too. The thesis was easy to find online from the university's site but I haven't read it properly yet. Interesting nevertheless. The thesis is titled "Aging and mitochondrial efficiency in the little brown bat, Myotis Lucifugus".
The second dissertation mentioned was about the effects of HIV on CD8+ T cell senescence.
Thursday, January 26, 2012
June 2003
Only reading abstracts.
"Telomere-Binding TRF2/MTBP Localization during Mouse Spermatogenesis and Cell Cycle of the Mouse Cells L929". Spot the telomere and the telomere membrane binding protein. Maybe I should be interested in this one, but don't seem to be.
A review of Werner's and Hutchinson-Gilford progerias.
A review of "Geriatric Medicine: an evidence based approach". Supposedly good.
An interesting new section called Dissertations, where they publish abstracts of thesis that are relevant. Very cool idea. I can only see the first one and a half. One about the roles of telomere-binding proteins have in telomere function in yeast, another one about targeting telomere and telomerase for cancer treatment, maybe mainly with a combination of paclitaxel, which damages telomeres, and AZT, which inhibits telomerase.
The review of the literature looks at a paper about the relationship between telomere length and Alzheimer's, stroke, and vascular dementia patients. I can't tell what happened since the results are on the second page, but going by the title of the paper, vascular dementia patients probably have shorter telomeres. (PS: actually, the paper is available in full, and yes, people with vascular dementia seem to have shorter telomeres on their peripheral blood mononuclear cells)
"Telomere-Binding TRF2/MTBP Localization during Mouse Spermatogenesis and Cell Cycle of the Mouse Cells L929". Spot the telomere and the telomere membrane binding protein. Maybe I should be interested in this one, but don't seem to be.
A review of Werner's and Hutchinson-Gilford progerias.
A review of "Geriatric Medicine: an evidence based approach". Supposedly good.
An interesting new section called Dissertations, where they publish abstracts of thesis that are relevant. Very cool idea. I can only see the first one and a half. One about the roles of telomere-binding proteins have in telomere function in yeast, another one about targeting telomere and telomerase for cancer treatment, maybe mainly with a combination of paclitaxel, which damages telomeres, and AZT, which inhibits telomerase.
The review of the literature looks at a paper about the relationship between telomere length and Alzheimer's, stroke, and vascular dementia patients. I can't tell what happened since the results are on the second page, but going by the title of the paper, vascular dementia patients probably have shorter telomeres. (PS: actually, the paper is available in full, and yes, people with vascular dementia seem to have shorter telomeres on their peripheral blood mononuclear cells)
Tuesday, January 24, 2012
March 2003, sadly without access
I'm still only reading the abstracts, but in this one there were two that sounded interesting, but I couldn't find them around.
"Early Programming of Adult Longevity: Demographic and Experimental Studies". They look at 100,000 people that died in the 1990s in Kiev and see a "strong association" between the month of the year they were born in and longevity, with the lowest longevity for people born April to July, and highest around December. The July and December low/high agree with what the Gavrilovs found in their studies of aristocratic families (see http://readingrejuvenationresearch.blogspot.com/2011/02/season-of-birth-and-human-longevity.html ) . On a seemingly completely unrelated study, they look at the lifespan of fruit flies and see them living longer when they are irradiated with low doses of radiation. Their hypothesis is that both effects, and many other anti-aging treatments, are due to the hormetic effect (ie response to low level stressor). Would like to read this one.
"Neuroprotective, Anti-Apoptotic Effects of Apomorphine". Looks at apomorphine's effects on the brain, with the possible focus on Parkinson's.
"The Role of Somatic and Germline Mutations in Aging and a Mutation Interaction Model of Aging". Another interesting one. Seems like a theoretical paper on the effect of accumulated mutations that don't affect us negatively until past reproductive age. Hypothesises that some of this could increase mutations in non-reproductive cells, leaving different random mutations around the body as we age.
The literature review section looks at a paper which lengthens telomeres in vitro by inserting a short circular bit of DNA matching the telomere repetition sequence's complement. The review has some concerns about validity and missing information to show that this did actually happen.
"Early Programming of Adult Longevity: Demographic and Experimental Studies". They look at 100,000 people that died in the 1990s in Kiev and see a "strong association" between the month of the year they were born in and longevity, with the lowest longevity for people born April to July, and highest around December. The July and December low/high agree with what the Gavrilovs found in their studies of aristocratic families (see http://readingrejuvenationresearch.blogspot.com/2011/02/season-of-birth-and-human-longevity.html ) . On a seemingly completely unrelated study, they look at the lifespan of fruit flies and see them living longer when they are irradiated with low doses of radiation. Their hypothesis is that both effects, and many other anti-aging treatments, are due to the hormetic effect (ie response to low level stressor). Would like to read this one.
"Neuroprotective, Anti-Apoptotic Effects of Apomorphine". Looks at apomorphine's effects on the brain, with the possible focus on Parkinson's.
"The Role of Somatic and Germline Mutations in Aging and a Mutation Interaction Model of Aging". Another interesting one. Seems like a theoretical paper on the effect of accumulated mutations that don't affect us negatively until past reproductive age. Hypothesises that some of this could increase mutations in non-reproductive cells, leaving different random mutations around the body as we age.
The literature review section looks at a paper which lengthens telomeres in vitro by inserting a short circular bit of DNA matching the telomere repetition sequence's complement. The review has some concerns about validity and missing information to show that this did actually happen.
Friday, January 20, 2012
December 2002, briefly
No content still. Almost nothing interesting either.
"Effect of DL-α-Lipoic Acid on the Status of Lipids and Membrane-Bound ATPases in Various Brain Regions of Aged Rats". Shoved lipoic acids into rats, levels of lipids in the brain went down. Had to double-check to make sure it wasn't the same paper as in the previous issue
"Comparison of a Broad Spectrum Anti-Aging Nutritional Supplement with and without the Addition of a DNA Repair Enhancing Cat's Claw Extract". They gave what sounds like a multi-vitamin with or without added cat claw extract to humans (?).
"A Comparison of Growth Hormone Administration and Exercise in the Elderly". Probably what it says. I could only read the introduction.
"The Third Annual Monte Carlo Anti-Aging Conference". This I wouldn't have minded reading.
A review of the book "Oxidative stress biomarkers and antioxidant protocols". Lab methods.
The literature review looking at a paper that gave amyloid beta peptides to embryonic mouse neurons and to some tumour line, and watched for effects on telomeres and telomerase.
"Effect of DL-α-Lipoic Acid on the Status of Lipids and Membrane-Bound ATPases in Various Brain Regions of Aged Rats". Shoved lipoic acids into rats, levels of lipids in the brain went down. Had to double-check to make sure it wasn't the same paper as in the previous issue
"Comparison of a Broad Spectrum Anti-Aging Nutritional Supplement with and without the Addition of a DNA Repair Enhancing Cat's Claw Extract". They gave what sounds like a multi-vitamin with or without added cat claw extract to humans (?).
"A Comparison of Growth Hormone Administration and Exercise in the Elderly". Probably what it says. I could only read the introduction.
"The Third Annual Monte Carlo Anti-Aging Conference". This I wouldn't have minded reading.
A review of the book "Oxidative stress biomarkers and antioxidant protocols". Lab methods.
The literature review looking at a paper that gave amyloid beta peptides to embryonic mouse neurons and to some tumour line, and watched for effects on telomeres and telomerase.
Thursday, January 19, 2012
September 2002 issue
Only abstracts. Another relatively thin issue, with only three papers, none of them very interesting.
"α-Lipoic Acid Enhances Reduced Glutathione, Ascorbic Acid, and α-Tocopherol in Aged Rats". Shoved lipoic acid into rats, levels of lipid peroxidation went down, and levels of vitamins C and E, and of reduced glutathione went up.
"Telomere Dynamics, Aging, and Cancer: Study of Human Syndromes Characteristic of Premature Aging". Looks at telomere length and endoreduplication (DNA replication outside cell replication) in Fanconi's anaemia, ataxia-telangiectasia, Bloom syndrome and xeroderma pigmentosum syndrome, all predisposing for cancer. Telomeres mostly shorter (not in xeroderma pigmentosum).
"Age-Related Susceptibility of Chemical Carcinogenesis in BALB/c Mice". They inject carcinogens into young, middle and old aged mice, count the number that get cancer (4/10, 10/10, and 1/10 respectively).
Literature review section again looks at an old paper, but one I hadn't heard of before, that analyses how much telomerase is active in young, middle and old aged rainbow trouts. Lots of telomerase activity everywhere at all ages, even compared to human tumour cells. Levels in muscle and brain cells down to human tumour cell levels. The title of the paper is 'Telomerase activity in "immortal" fish'. Do rainbow trouts not age? Couldn't find anything on a brief search.
"α-Lipoic Acid Enhances Reduced Glutathione, Ascorbic Acid, and α-Tocopherol in Aged Rats". Shoved lipoic acid into rats, levels of lipid peroxidation went down, and levels of vitamins C and E, and of reduced glutathione went up.
"Telomere Dynamics, Aging, and Cancer: Study of Human Syndromes Characteristic of Premature Aging". Looks at telomere length and endoreduplication (DNA replication outside cell replication) in Fanconi's anaemia, ataxia-telangiectasia, Bloom syndrome and xeroderma pigmentosum syndrome, all predisposing for cancer. Telomeres mostly shorter (not in xeroderma pigmentosum).
"Age-Related Susceptibility of Chemical Carcinogenesis in BALB/c Mice". They inject carcinogens into young, middle and old aged mice, count the number that get cancer (4/10, 10/10, and 1/10 respectively).
Literature review section again looks at an old paper, but one I hadn't heard of before, that analyses how much telomerase is active in young, middle and old aged rainbow trouts. Lots of telomerase activity everywhere at all ages, even compared to human tumour cells. Levels in muscle and brain cells down to human tumour cell levels. The title of the paper is 'Telomerase activity in "immortal" fish'. Do rainbow trouts not age? Couldn't find anything on a brief search.
Wednesday, January 18, 2012
June 2002 by the very few abstracts
Still without access and nothing here that would make them look hard for them elsewhere. Quite a light issue overall.
"Vitamin E and Age Alter Liver Mitochondrial Morphometry". Mice liver's mitochondria measured across different ages and vitamin E supplementation. Mitochondria smaller in vitamin E'd mice compared to controls in old mice. Also, as mice get older, their mitochondria elongate, also in vitamin E'd mice. I had no idea that mitochondria elongated with age.
"In Search of a Model Species for Aging Research: A Study of the Life Span of Tree Shrews". Using shrews for animal aging as a shortish-life (10-14 years) but evolutionary close animals (close compared to mice).
A review of de Grey's book "The mitochondrial free radical theory of aging".
The regular literature review column reviewing the original telomerase-gets-fibroblasts-to-replicate-and-not-look-senescent paper.
There was also a letter to the editor that I should read if I ever read Arking's paper on mortality plateau from last issue that looked interesting.
"Vitamin E and Age Alter Liver Mitochondrial Morphometry". Mice liver's mitochondria measured across different ages and vitamin E supplementation. Mitochondria smaller in vitamin E'd mice compared to controls in old mice. Also, as mice get older, their mitochondria elongate, also in vitamin E'd mice. I had no idea that mitochondria elongated with age.
"In Search of a Model Species for Aging Research: A Study of the Life Span of Tree Shrews". Using shrews for animal aging as a shortish-life (10-14 years) but evolutionary close animals (close compared to mice).
A review of de Grey's book "The mitochondrial free radical theory of aging".
The regular literature review column reviewing the original telomerase-gets-fibroblasts-to-replicate-and-not-look-senescent paper.
There was also a letter to the editor that I should read if I ever read Arking's paper on mortality plateau from last issue that looked interesting.
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