Monday, February 10, 2014

Issue 3, 2006

By the abstracts:

"Targeting Telomerase". Review of techniques and issues regarding hammering telomerase as an anti-cancer treatment, and whether that would select for ALT-cancers (ALT constitute 10-15% of cancers atm). Of note, the existence of a TERT vaccine.

"Telomere and TRF2/MTBP Localization in Respect to Satellite DNA During the Cell Cycle of Mouse Cell Line L929" About what happens to telomeres as the cells goes through its cycle in mice. Mostly goes over my head.

"Werner Syndrome as an Example of Inflamm-aging: Possible Therapeutic Opportunities for a Progeroid Syndrome?" Title is a good summary of the abstract.

"Stimulation of Macroautophagy Can Rescue Older Cells from 8-OHdG mtDNA Accumulation: A Safe and Easy Way to Meet Goals in the SENS Agenda" They stimulate macroautophagy by injecting agents that stop the breakdown of triglycerides in rat liver cells. This gets rid of 8-OHdG accumulation in the mtDNA in six hours.

Also, a report on SENS 2 by Aubrey de Grey that I'd like to read.

Overall, I don't mind as much not having access to the articles in this issue.

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