Rest of volume 2, Issue 4

The rest of issue 4 of 1999 consists of:

A review of a book called Essentials of Clinical Geriatrics, 4th edition, edited by Robert L Kane, Joseph G Ouslander and
Itamar B Abrass. "Concise" 621 pages of differences between geriatric and standard medicine.


Seven article reviews by L Stephen Coles:

• Gene expression profile of aging and its retardation by caloric restriction, by Cheoi-Koo Lee, Roger G Klopp, Richard Weindruch and Tomas A Prolla, in Science. Analysis of what genes change in muscle cells in old mice compared to young mice compared to old calorie restricted mice using a gene chip of 6000 genes. Lots of changes, with caloric restriction reducing the changes by 84%. L Stephen Coles thought this was a very important paper.
  
• Can human aging be postponed?, by Michael R Rose, in Scientific American. Some pop-sci sounding piece.
• Designer genomes, by Karen Hopkin, in Scientific American. Another pop-sci sounding piece about creating cells from scratch. Mentions Venter's knock out method of finding the minimal set. I didn't know he had been going at it that long.
• Telomeres and telomerase in cancer, by Christopher M Counter, in Science and Medicine. Supposedly nice graphics.
• Aging: The price of evolutionary success, by Robert F Rosenberger, in Science Spectra: The international magazine of contemporary scientific thought. About germ vs soma.
• The hunt for the youth pill: From cell-immortalizing drugs to cloned organs, biotech finds new ways to fight against time's toll, by David Stipp, in Fortune Magazine.
• Never say die, by Lisa Leff, in the Los Angeles Magazine.