Summary: Hypothesising that humans select against deadly mutations primarily at the zygote stage.
Interestingness: 4
Paper by Leonid A Gavrilov and Natalia S Gavrilova, in the Journal of Anti-Aging Medicine, Volume 2, Issue 2, Summer 1999.
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Another short note, this one on how come the human race still exists considering the large amount of mutations that occur during each generation. They quote a number from a different study claiming 1.6 new harmful mutations per person, per generation. Their suggested mechanism on how to select against deadly combinations is by being very sensitive at the zygote stage, so having the deaths happen early. Their evidence for this is that the time lag between marriage and first child is around 16-19 months, giving time for about 7-10 failures. Doesn't sound like impressive evidence to me, but the idea is appealing anyway. They don't offer a mechanism as far as I can see on how the zygote is made so sensitive to deadly mutations.
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